SHENLin-lu,SHENJi-min,KANGJing,et al.Online Solid Phase Extraction Coupled With High Performance Liquid Chromatography for Rapid Determination of N-nitrosodimethylamine in Water[J].China Water & Wastewater,2023,39(2):133-138.
Online Solid Phase Extraction Coupled With High Performance Liquid Chromatography for Rapid Determination of N-nitrosodimethylamine in Water
China Water & Wastewater[ISSN:1000-4062/CN:12-1073/TU]
volume:
第39卷
Number:
第2期
Page:
133-138
Column:
Date of publication:
2023-01-17
- Keywords:
- N-nitrosodimethylamine (NDMA); rapid determination method; online solid phase extraction (online SPE); high performance liquid chromatography (HPLC); diode array detector (DAD)
- Abstract:
-
Rapid and accurate quantitative determination of N-nitrosodimethylamine (NDMA) in water has always been a difficult problem concerned by researchers at home and abroad. A method for rapid determination of NDMA in water was developed based on online solid phase extraction coupled with high performance liquid chromatography (online SPE-HPLC). After the water samples were enriched online by Hypersil GOLD aQ solid phase extraction column, the flow direction of the pipeline was changed through a six-way valve switch, acetonitrile and water were used as the mobile phase for elution of NDMA, and the components were separated by Thermo Acclaim PA Ⅱ column and detected by diode array detector (DAD). The limit of detection (LOD) of this method was 0.025
g/L, and the limit of quantification (LOQ) was 0.07 g/L. NDMA had good linearity in the range of 0.09-20 g/L (R 2 =0.999 7), the recoveries of NDMA were 95.28%-114.93%, and the relative standard deviation was less than 9.72%. The method only consumed 2.5 mL sample volumes and could automatically realize solid phase extraction, elution and analysis of samples in 10 min. The method does not require complex manual pretreatment process, and it is simple, quick and cost?effective, and can achieve rapid and accurate detection of NDMA concentration in water samples, which can meet the requirements of drinking water standards for NDMA detection in China.
Last Update:
2023-01-17