FUZheng-wei,ZHUFeng,HUOZong-li,et al.Determination of 52 Pharmaceuticals and Personal Care Products in Water by HPLC-MS/MS[J].China Water & Wastewater,2023,39(4):127-138.
Determination of 52 Pharmaceuticals and Personal Care Products in Water by HPLC-MS/MS
China Water & Wastewater[ISSN:1000-4062/CN:12-1073/TU]
volume:
第39卷
Number:
第4期
Page:
127-138
Column:
Date of publication:
2023-02-17
- Abstract:
- The effects of different sample pretreatment methods on high performance liquid chromatography tandem mass spectrometry (HPLC-MS/MS) for the determination of 52 kinds of pharmaceutical and personal care products (PPCPs) in water were investigated to improve the accuracy and stability of the determination method. HPLC-MS/MS was used to determine the concentration difference of PPCPs in water samples after different pretreatment methods (transferring by different materials of dropper, whether to avoid light, storage time, centrifugation and filtration by different filter membranes), and then the pretreatment conditions of samples were optimized. The maximum loss ratio of PPCPs in water caused by polyethylene plastic dropper transferring, avoiding light and without avoiding light placing for 8 h was 36.4%, 51.7% and 60.2%, respectively. After centrifugation or filtration with three different materials (PTFE, NL66 and MCE), the recovery rates of 52 PPCPs were 0.0% to 114.2%. The result of the the tap water spiked experiment revealed that the recovery rates of 46 PPCPs, except five macrolides antibiotics and Virginiamycin S1, were all ≥73.3% after the filtration with the corresponding best filter membranes. The results indicated that some PPCPs in water were easy to be adsorbed, self-degraded or photodegraded, and the detection results of low concentration PPCPs were underestimated by means of centrifugation and filtration. Therefore, the samples should be placed avoiding light before determination, and the analysis should be completed within 8 h after sampling. In addition, the use of plastic products such as polyethylene dropper and polypropylene centrifuge tube should be avoided, and make sure that the filter membrane will not absorb the PPCPs to be tested.
Last Update:
2023-02-17