HOUYun-he,DONGZi-jun,SONGHong-xing,et al.Simultaneous Detection of Eight Antiviral Drugs for Treatment of COVID-19 in Source Water[J].China Water & Wastewater,2022,38(22):130-134.
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Simultaneous Detection of Eight Antiviral Drugs for Treatment of COVID-19 in Source Water

China Water & Wastewater[ISSN:1000-4062/CN:12-1073/TU] volume: 第38卷 Number: 第22期 Page: 130-134 Column: Date of publication: 2022-11-17
Author(s):
HOU　Yun-he1; 2;  DONG　Zi-jun2; 3;  SONG　Hong-xing4;  LI　Wei1;  YAN　Yun4;  WANG　Lu4
（1. School of Municipal and Environmental Engineering， Shenyang Jianzhu University， Shenyang 110168， China； 2. School of Materials & Environmental Engineering， Shenzhen Polytechnic， Shenzhen 518055， China； 3. College of Civil and Transportation Engineering， Shenzhen University， Shenzhen 518055， China； 4. Shenzhen Hydrology and Water Quality Center， Shenzhen 518055， China）
Keywords:
antiviral drugs;  detection method;  source water;  LC-MS/MS
Abstract:
The continuous outbreak of COVID-19 results in a large number of therapeutic drugs inevitably entering water bodies through different pathways, and there are problems of accurate and rapid detection in the treatment and ecological evaluation of these drugs. Therefore, it is necessary to establish a method for simultaneous detection of multiple antiviral drugs for treatment of COVID-19 in water. A method for the simultaneous detection of 8 antiviral drugs (ribavirin, oseltamivir, nevirapine, lamivudine, abacavir, stavudine, acyclovir and penciclovir) in source water was developed by optimizing the determining parameters of liquid chromatography-tandem mass spectrometry (LC-MS/MS). The daughter ion response values of 8 antiviral drugs in this method were relatively high, which was beneficial to the detection of target compounds. The correlation coefficient (r) of the standard curve of 8 antiviral drugs was not less than 0.995 0, the method detection limit (MDL) and the lower limit of determination were in the range of 0.004-0.081 μg/L and 0.013-0.267 μg/L, respectively, and the spike recoveries and RSDs of actual water samples were 81.61%-113.03% and 0.84%-8.12%, respectively.
Last Update: 2022-11-17