ZHAOMing-ming,LIUDong-xian,WULan,et al.Solid Phase Extraction/Ultra Performance Liquid Chromatography-Tandem Mass Spectrometry for Determination of 14 Drugs and Their Metabolites in Wastewater[J].China Water & Wastewater,2022,38(24):133-138.
Solid Phase Extraction/Ultra Performance Liquid Chromatography-Tandem Mass Spectrometry for Determination of 14 Drugs and Their Metabolites in Wastewater
China Water & Wastewater[ISSN:1000-4062/CN:12-1073/TU]
volume:
第38卷
Number:
第24期
Page:
133-138
Column:
Date of publication:
2022-12-17
- Keywords:
- wastewater; LC-MS/MS; drugs; content determination
- Abstract:
- This paper established a method of solid phase extraction/ultra performance liquid chromatography-tandem mass spectrometry for determination of 14 common drugs and their metabolites in wastewater. Wastewater samples were enriched by MCX solid phase extraction column, purified with ultrapure water, and eluted with methanol and 5% ammonia methanol solution respectively. After nitrogen blowing, ultra performance liquid chromatography-tandem mass spectrometry was used for detection. The linearity of 14 common drugs and their metabolites was good when their concentrations were in the range of 1.0-500 ng/L and population marker cotinine was in the range of 10-5 000 ng/L. The correlation coefficient R2 was greater than 0.999, the detection limit (S/N of 3) of drugs and their metabolites was 0.2-0.5 ng/L, and the spike recovery rate of wastewater ranged from 70.00% to 115.57%. The method was applied to detect the inlet wastewater of 8 sewage treatment plants in Hunan Province, and the reliability of the method was verified, which provided a reference for further establishment of regional drug abuse assessment methods.
Last Update:
2022-12-17