[1]刘然彬,郝晓地,Mark van Loosdrecht,等.污水流行病学用于新冠肺炎预警研究进展[J].中国给水排水,2021,37(14):37-45.
LIU Ran-bin,HAO Xiao-di,Mark van Loosdrecht,et al.Research Progress of Wastewater-based Epidemiology as an Early Warning System for COVID-19 Pandemic[J].China Water & Wastewater,2021,37(14):37-45.
点击复制
LIU Ran-bin,HAO Xiao-di,Mark van Loosdrecht,et al.Research Progress of Wastewater-based Epidemiology as an Early Warning System for COVID-19 Pandemic[J].China Water & Wastewater,2021,37(14):37-45.
污水流行病学用于新冠肺炎预警研究进展
中国给水排水[ISSN:1000-4062/CN:12-1073/TU]
卷:
第37卷
期数:
2021年第14期
页码:
37-45
栏目:
出版日期:
2021-07-17
- Title:
- Research Progress of Wastewater-based Epidemiology as an Early Warning System for COVID-19 Pandemic
- Keywords:
- COVID-19; water-based epidemiology; early warning of epidemic disease; virus detection; RNA
- 摘要:
- 突发新型冠状病毒肺炎（COVID-19）已蔓延至全球几乎所有国家，累计确诊病例已超过1亿例。这一全球大流行病尽管现阶段在我国多点散发，但已得到基本控制，由于不容乐观的全球疫情扩散，依然存在疫情反弹之巨大风险。在新冠疫苗实现大规模接种之前，COVID-19暴发有效预警机制依然是最需要的技术手段。鉴于感染者粪便/尿液中存在病毒粒子或遗传物质核糖核酸（RNA），荷兰学者提出了基于污水流行病学（WBE）监控SARS-CoV-2（诱发COVID-19的病毒）出现并传播的设想。目前，污水中SARS-CoV-2有限RNA检测研究结果已经证明了这一技术作为疫情预警的可行性，亦可能根据WBE检测结果表征病毒传播动态与趋势、估算感染群体比例，甚至在一定范围内进行感染群体追踪。在总结WBE技术在我国发展应用的基础上，对已有污水中SARS-CoV-2的核酸检测研究结果、应用价值和指导意义进行综合分析，总结WBE研究标准化方案，辨析亟需深入研究的方向领域。这对我国下一阶段疫情防控具有相当启发与参考价值。
- Abstract:
- The New Corona Virus Disease (COVID-19) has spread to almost all countries in the world with the cumulative number of confirmed cases reaching 100 million cases. Although the virus spread has been under control in China with occasional cases reported at this stage, there is still a huge risk of the epidemic rebound due to the external unfavorable situation. Before the virus vaccination covers a large group of people, an effective early warning system of COVID-19 outbreak is still the most needed technical means. In view of the presence of virus particles or genetic material (RNA) in the feces/urine of infected cases, Dutch researcher firstly proposed the idea of monitoring SARS-CoV-2 via wastewater-based epidemiology (WBE). So far, the preliminary studies have proved the feasibility of this technology on SARS-CoV-2 surveillance as an early warning. WBE may also characterize the virus transmission dynamics and trends, estimate the prevalence of infected cases, and even locate the infected cases. The present review firstly summarized the development and application of WBE technology in China. Then, a comprehensive analysis was conducted regarding so far what we know about WBE and what WBE can do for us in terms of SARS-CoV-2 surveillance. Finally, a standard protocol for WBE implementation and the areas for further research were presented. Overall, this work is expected to convey timely information and be a reference for the further epidemic control in China.
更新日期/Last Update:
2021-07-19