[1]侯云鹤,董紫君,宋洪星,等.水源水中8种治疗新冠的抗病毒药物的同步检测[J].中国给水排水,2022,38(22):130-134.
　HOUYun-he,DONGZi-jun,SONGHong-xing,et al.Simultaneous Detection of Eight Antiviral Drugs for Treatment of COVID-19 in Source Water[J].China Water & Wastewater,2022,38(22):130-134.
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水源水中8种治疗新冠的抗病毒药物的同步检测

中国给水排水[ISSN:1000-4062/CN:12-1073/TU] 卷: 第38卷 期数: 2022年第22期 页码: 130-134 栏目: 出版日期: 2022-11-17
Title:
Simultaneous Detection of Eight Antiviral Drugs for Treatment of COVID-19 in Source Water
作者:
侯云鹤1,2， 董紫君2,3， 宋洪星4， 李微1， 闫韫4， 王路4
（1.沈阳建筑大学 市政与环境工程学院，辽宁 沈阳 110168；2.深圳职业技术学院 材料与环境工程学院，广东 深圳 518055；3.深圳大学 土木与交通工程学院，广东 深圳 518055；4.深圳市水文水质中心，广东 深圳 518055）
Author(s):
HOU　Yun-he1，2， DONG　Zi-jun2，3， SONG　Hong-xing4， LI　Wei1， YAN　Yun4， WANG　Lu4
（1. School of Municipal and Environmental Engineering， Shenyang Jianzhu University， Shenyang 110168， China； 2. School of Materials & Environmental Engineering， Shenzhen Polytechnic， Shenzhen 518055， China； 3. College of Civil and Transportation Engineering， Shenzhen University， Shenzhen 518055， China； 4. Shenzhen Hydrology and Water Quality Center， Shenzhen 518055， China）
关键词:
抗病毒药物;  检测方法;  水源水;  LC-MS/MS
Keywords:
antiviral drugs;  detection method;  source water;  LC-MS/MS
摘要:
随着新冠疫情的持续暴发，大量治疗药物不可避免地从不同途径进入水体，在对其进行治理和生态评价时面临准确、快速检测的问题，需要建立同步分析水中多种治疗新冠的抗病毒药物的方法。通过对液相色谱-串联质谱（LC-MS/MS）的测定条件进行优化，构建了一种同步检测水源水中利巴韦林、奥司他伟、奈韦拉平、拉米夫定、阿巴卡韦、司他夫定、阿昔洛韦、喷昔洛韦等8种抗病毒药物的方法。结果表明，该方法的8种抗病毒药物的子离子响应值相对较高，有利于目标化合物的检测；8种抗病毒药物的标准曲线的线性相关系数（r）≥0.995 0，检出限（MDL）和测定下限分别为0.004~0.081、0.013~0.267 μg/L，实际水样的加标回收率与RSD分别为81.61%~113.03%、0.84%~8.12%。
Abstract:
The continuous outbreak of COVID-19 results in a large number of therapeutic drugs inevitably entering water bodies through different pathways, and there are problems of accurate and rapid detection in the treatment and ecological evaluation of these drugs. Therefore, it is necessary to establish a method for simultaneous detection of multiple antiviral drugs for treatment of COVID-19 in water. A method for the simultaneous detection of 8 antiviral drugs (ribavirin, oseltamivir, nevirapine, lamivudine, abacavir, stavudine, acyclovir and penciclovir) in source water was developed by optimizing the determining parameters of liquid chromatography-tandem mass spectrometry (LC-MS/MS). The daughter ion response values of 8 antiviral drugs in this method were relatively high, which was beneficial to the detection of target compounds. The correlation coefficient (r) of the standard curve of 8 antiviral drugs was not less than 0.995 0, the method detection limit (MDL) and the lower limit of determination were in the range of 0.004-0.081 μg/L and 0.013-0.267 μg/L, respectively, and the spike recoveries and RSDs of actual water samples were 81.61%-113.03% and 0.84%-8.12%, respectively.

相似文献/References:

[1]董露露,姚振兴,刘莉,等.饮用水中卤代含氮消毒副产物检测及生成研究进展[J].中国给水排水,2023,39(20):44.
　DONGLu-lu,YAOZhen-xing,LIULi,et al.Research Progress in the Detection and Formation of Halogenated Nitrogenous Disinfection By?products in Drinking Water[J].China Water & Wastewater,2023,39(22):44.

更新日期/Last Update: 2022-11-17