[1]张欢欢,韩乐迪,郭宁,等.盐度对硝化污泥系统去除抗生素过程中ARGs的影响[J].中国给水排水,2025,41(3):72-77.
　ZHANGHuan-huan,HANLe-di,GUONing,et al.Impact of Salinity on Antibiotic Resistance Genes during Antibiotics Removal in Nitrifying Sludge System[J].China Water & Wastewater,2025,41(3):72-77.
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盐度对硝化污泥系统去除抗生素过程中ARGs的影响

中国给水排水[ISSN:1000-4062/CN:12-1073/TU] 卷: 第41卷 期数: 2025年第3期 页码: 72-77 栏目: 出版日期: 2025-02-01
Title:
Impact of Salinity on Antibiotic Resistance Genes during Antibiotics Removal in Nitrifying Sludge System
作者:
张欢欢1， 韩乐迪1， 郭宁1,2， 赵学宇1， 王琳1,2， 张志斌1
（1.山东建筑大学 市政与环境工程学院，山东 济南 250101；2.山东建筑大学 资源与环境创新研究院，山东 济南 250101）
Author(s):
ZHANG　Huan-huan1， HAN　Le-di1， GUO　Ning1，2， ZHAO　Xue-yu1， WANG　Lin1，2， ZHANG　Zhi-bin1
（1. School of Municipal and Environment Engineering， Shandong Jianzhu University， Jinan 250101， China； 2. Resources and Environment Innovation Institute， Shandong Jianzhu University， Jinan 250101， China）
关键词:
硝化污泥;  抗生素;  盐度;  抗性基因;  微生物群落
Keywords:
nitrifying sludge;  antibiotics;  salinity;  antibiotic resistance genes (ARGs);  microbial community
摘要:
硝化污泥工艺可以有效去除抗生素，然而盐度对硝化污泥系统去除抗生素过程中抗性基因（ARGs）的影响尚不清楚。为此，研究了不同盐度（0、0.5%、1.0%和2.0%）对硝化污泥系统去除磺胺嘧啶（SDZ）性能的影响，同时利用微生物学和统计学方法探究了盐度对ARGs的影响机理，并分析了不同盐度条件下系统的微生物群落结构变化。结果表明，高盐度通过抑制抗生素降解菌（氨氧化菌和异养菌）的活性而降低对抗生素的去除率，2.0%盐度下SDZ的去除率仅为42.3%。另外，盐度对ARGs的影响是水平基因转移和微生物群落变化共同作用的结果，提高盐度会促进ARGs的增殖。在低盐度（0.5%）时ARGs丰度最高，其中sul1和sul2的丰度分别为3.79×10-4、2.97×10-4 copies（以16S rRNA为标准）。
Abstract:
The nitrifying sludge process has been shown to effectively eliminate antibiotics; however, the impact of salinity on the removal of antibiotic resistance genes (ARGs) within the nitrifying sludge system remains poorly understood. In this paper, the impact of varying salinities (0, 0.5%, 1.0%, and 2.0%) on the performance of the nitrifying sludge system in treating sulfadiazine (SDZ) wastewater was investigated. Concurrently, the impact mechanisms of salinity on ARGs were examined using microbiological and statistical methods, and the microbial community composition under different salinity conditions was characterized. High salinity significantly reduced the antibiotic removal efficiency by inhibiting the activity of antibiotic-degrading bacteria, including ammonia-oxidizing bacteria and heterotrophic bacteria. Specifically, at a salinity level of 2.0%, the removal efficiency of sulfadiazine (SDZ) was only 42.3%. Furthermore, the impact of salinity on ARGs was attributed to horizontal gene transfer and alterations in microbial community composition. Elevated salinity was likely to promote the proliferation of ARGs. The highest abundance of ARGs was observed at a low salinity of 0.5%, with the abundances of sul1 and sul2 being 3.79×10-4 copies and 2.97×10-4 copies（Standardized with 16S rRNA), respectively.

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更新日期/Last Update: 2025-02-01